Dr. Malek’s

MTHFRSolve

For people who’ve tried everything.

Here’s (almost) everything I offer:

  • Methylation Genetics + Personal Video Analysis/Supplement Plan

    Get a check swab to see how your genes affect methylation, detox, and energy pathways (including MTHFR and COMT, of course) and I’ll record myself analyzing your results and producing your supplement plan on my screen.

    Get your cheek swab

  • Mood Genetics + Personal Video Analysis/Supplement Plan

    This is a cheek swab too, but the genes tested are targeted towards things that affect serotonin, dopamine, and stress chemistry (and therefore anxiety, low mood, irritability, or sleep disruption). Also includes a video analysis.

    Get your cheek swab

  • Methylation Genetics + Biomarkers + Live Consult

    Cheek swab (genetics) + Blood test (methylation biomarkers) + live 45-minute consult to talk about what it all means.

    Get your cheek swab + blood draw pack

  • Upload Your Data + Personal Video Analysis

    Upload any genetic data, blood labs, etc. that you have and I’ll study all of it and produce a screenshare video analysis with my thoughts.

    Upload your data

  • Consult (30 - 60 minutes)

    Schedule a live video consult with me. You’ll have the opportunity to upload any data/history you want me to see beforehand.

    Check the schedule

Testimonials from my beloved clients and patients:

“Confirmed lifelong issues that doctors were unwilling or could not fix…”

~ Michael

“This level of guidance is rare to find.”

~ Anonymous customer

“Far superior to the more expensive offering from the competition! :-)”

~ Todd

“This is the best genetic testing kit on the market.”

~ Dexter

“This is honestly already the best help I’ve ever gotten.”

~ Wellness Client from North Carolina

“Putting aside earning money fast so they can focus on the tests they already have proves to me that money isn't their first concern, health is.”

~ Debbie

“I really don’t have faith in anyone else being able to do what you do and help me like you have.”

~ Wellness Client from California

Disclaimer: The testimonials displayed on this website reflect individual client experiences with either licensed medical care or educational wellness services. Medical services are available only to residents of states where Dr. Malek is licensed to practice (currently Florida, Texas, Arizona, and Minnesota). Educational services offered to clients in other regions are not medical care, do not establish a doctor-patient relationship, and are not intended to diagnose, treat, cure, or prevent any disease. Individual results vary, and no outcome is guaranteed.

About me:

Dr. Malek Hamed

MTHFRSolve is my brainchild.

I’m an IFM-trained Functional Medicine physician* with experience solving a wide variety of disorders still seen as mysterious by the modern medical paradigm.

I love solving those mysterious problems.*

But doing so requires two things that are, unfortunately, much too rare in our times: Authenticity and Depth.

MTHFRSolve is my way of bringing those back.

~ Dr. Malek
admin@malekmd.com

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Email me

*If you live in a state where I’m licensed, I offer full-spectrum online medicine services. If you're outside those regions, I provide non-medical wellness consultations designed to help you unlock what’s holding you back, using your genetics, labs, and unique biology.

I started this ultra-small, Florida-based company with the aim of providing the most in-depth, scientifically accurate, and personalized genetic and functional guidance possible.

I enforce the following rigorous standards upon my tiny team:

~ Your Health Data Stays PRIVATE~
I follow strict confidentiality standards so your information is never shared unless you ask for it. I consider that immoral.

~ Expert Interpretation & Strategy ~
Every insight, plan, and recommendation comes directly from me, a highly-trained MD, not a script or assistant.

~ Actionable Guidance ~
I won’t just send you numbers. I’ll teach you what they mean and how to use them to improve your health.

~ Super Convenient, Accessible Process ~
Whether genetic kits, lab orders, or follow-up consults, I will absolutely try my best to make things as easy as possible for you all.

Note: Genetic and functional testing services are provided via third-party laboratories. Interpretation is for educational and wellness purposes and does not constitute medical advice unless delivered through a licensed medical consultation in an eligible state.

If you’re not sure where to start, get my Comprehensive Methylation Panel:

“Wow, All I can say is this test has been incredibly helpful for both my daughter and my wife. It’s uncovered some major issues that we had not been able to diagnose with standard tests.”
— One of my clients

*FL, TX, AZ, and MN ONLY

MTHFRSolve Comprehensive Methylation Panel + COMT

One of the most comprehensive tests of methylation genetics on the market. Learn more

  • We test 26 spots on your DNA that are relevant to the process of methylation, including MTHFR, MTR, MTRR, AHCY, and more. Many competitors test only 5.

  • We test the highly important COMT gene SNP, a gene that affects how you process dopamine, adrenaline, and estrogen.

  • Your results come with in-depth supplement recommendations, including dosages, recorded over video by Dr. Malek (me) for your unique genetic variances.

from $399.00

“Thank you so much again for your patience, persistence and thoroughness…

So far, you're the only clinician I've worked with to date who's been able to move the needle on my various issues, and it's hard to express in words how thankful I am for that!”

— Former Client

Or schedule an open-ended consult:

*FL, TX, AZ, and MN ONLY (others click HERE)

Book a consultation

(I don’t treat insurance codes...)

If you’ve already seen five specialists, tried dozens of protocols, or been told repeatedly that “your labs look fine”…

Then welcome!

I work with people who are stuck in that exact place.

Whether it’s methylation dysfunction, neurotransmitter imbalance, fatigue, anxiety, food reactions, chronic toxicities, chronic viral injury, or symptoms no one can explain—I help patients unravel complex cases by developing the fullest biochemical picture possible.

These are not generic visits. You’ll get:

  • A full review of your history, symptoms, and prior labs

  • Integration of genetics, nutrition, lifestyle, and targeted biomarkers

  • Real strategy, grounded in your physiology—not insurance codes, CPT billing, or (frankly) broken algorithms.

ONLY for residents of Florida, Texas, Arizona, and Minnesota. (CLICK HERE for international customers and other US states! 🌍)

This is for you if:
You’re exhausted by formulaic medicine, you suspect something deeper is going on, and you want to paint the fullest picture of your current health possible.

“What a great program! The testing was simple and the results came back very quickly.”

— Todd

Or go back up and check out all my offerings:

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You can also check out my blog:

Featured
Grace…
Malek Hamed, MD
Grace…
Malek Hamed, MD
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Malek Hamed, MD
In this world of oil and steel…
Malek Hamed, MD
In this world of oil and steel…
Malek Hamed, MD

In this world of oil and steel, man is useful only insofar as he can fan the flames.

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Malek Hamed, MD
Tylenol, Autism, and Pregnancy—The Safe Way to Take it to Avoid the Potential Risk
Malek Hamed, MD
Tylenol, Autism, and Pregnancy—The Safe Way to Take it to Avoid the Potential Risk
Malek Hamed, MD

Recently, the FDA under the Trump administration took an initial step towards officially recognizing potential harms of Tylenol (acetaminophen, also called Paracetamol) supplementation during pregnancy.

The claim is that Tylenol has the potential to increase the risk of autism in the children of pregnant mothers who use it.

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Malek Hamed, MD
Slow COMT: The Definitive Clinical Guide for Testing and Optimization
Support @ MTHFRSolve
Slow COMT: The Definitive Clinical Guide for Testing and Optimization
Support @ MTHFRSolve

Slow COMT is a biochemical variant that can profoundly shape mood, stress tolerance, and even how you respond to vitamins or caffeine. If you’ve ever felt “tired but wired”— exhausted in body yet racing in mind—or found that B vitamins and coffee make you jittery and anxious, the slow COMT gene variant is very likely the hidden key.

In this comprehensive guide, we’ll show you clearly what COMT is (and the famous Val158Met polymorphism), how to identify a slow variant in your genetic data, and, most importantly, how to optimize your lifestyle and supplementation to feel better.

We’ll also highlight what to avoid (yes, there are “healthy” supplements that can backfire for slow COMT-ers). By the end, you’ll have a reasonably clear plan for managing a slow COMT.

Read More →
Support @ MTHFRSolve
What Supplements Should I Take for Histamine Intolerance
Support @ MTHFRSolve
What Supplements Should I Take for Histamine Intolerance
Support @ MTHFRSolve

Histamine intolerance can cause migraines, fatigue, gut problems, and skin reactions—without showing up on allergy tests. Here’s how to identify it, and what supplements can help you get relief without falling into common traps.

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Support @ MTHFRSolve
Should You Take Boswellia If You Have Slow COMT?
Malek Hamed, MD
Should You Take Boswellia If You Have Slow COMT?
Malek Hamed, MD

Boswellia is derived from the resin of a tree that's common through certain parts of Asia and Africa. People commonly use it for inflammatory issues, but I'm going to try to address whether this herb has any use and or harm for people with slow COMT variants specifically.

Read More →
Malek Hamed, MD
Slow COMT: The Ultimate Clinical Guide to Symptoms, Patterns, and Root Causes
Support @ MTHFRSolve
Slow COMT: The Ultimate Clinical Guide to Symptoms, Patterns, and Root Causes
Support @ MTHFRSolve

Slow COMT function affects how the brain and body clear dopamine, norepinephrine, and estrogen—contributing to anxiety, fatigue, supplement intolerance, and poor sleep. This guide explains the full range of symptoms, why they’re often missed, and what works to stabilize those biochemical pathways.

Read More →
Support @ MTHFRSolve
What Supplements Should You Take if You Have a COMT Mutation?
Malek Hamed, MD
What Supplements Should You Take if You Have a COMT Mutation?
Malek Hamed, MD

Generally speaking, if you have a “mutation” in this gene, what that really means is that you have an under-functioning polymorphism that is less effective at breaking down dopamine, estrogen, and other metabolites…

Read More →
Malek Hamed, MD
Supplements to Avoid with a Slow COMT
Malek Hamed, MD
Supplements to Avoid with a Slow COMT
Malek Hamed, MD

As you may remember from our previous articles, catechol-O-methyltransferase (COMT) is an enzyme that breaks down catecholamines (most relevantly, dopamine), undesirable forms of estrogen, and other toxic substances in the body…

Read More →
Malek Hamed, MD
The Complete Guide to Vitamin B6 Toxicity Symptoms—Even Without Supplements
Support @ MTHFRSolve
The Complete Guide to Vitamin B6 Toxicity Symptoms—Even Without Supplements
Support @ MTHFRSolve

Vitamin B6 toxicity doesn’t just happen to people taking megadoses. Tingling feet, insomnia, anxiety, heart palpitations, and mysterious nerve symptoms can appear even at low daily intakes—sometimes without any supplements at all. This guide breaks down the full spectrum of B6 toxicity symptoms, from subtle sensory changes to life-altering neurological dysfunction, and explains why “normal” blood levels and doses may not be safe for everyone.

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Support @ MTHFRSolve
Why Vitamin B6 Toxicity Can Happen at Just 2 mg Per Day (And What It Means If Your B6 Level Is High Without Supplements)
Support @ MTHFRSolve
Why Vitamin B6 Toxicity Can Happen at Just 2 mg Per Day (And What It Means If Your B6 Level Is High Without Supplements)
Support @ MTHFRSolve

Even doses of vitamin B6 as low as 2 mg per day—commonly found in multivitamins—have triggered severe nerve symptoms in genetically or metabolically susceptible individuals. This article walks through the science, symptoms, and lab patterns behind B6 overload without high-dose supplementation.

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Support @ MTHFRSolve
B6 Toxicity Without Supplements: What It Means and Why It Happens
Dr. Malek and the MTHFRSolve Team
B6 Toxicity Without Supplements: What It Means and Why It Happens
Dr. Malek and the MTHFRSolve Team

Can You Get B6 Toxicity Without Supplements? And what causes it?

Yes, you can. B6 toxicity without supplements occurs when plasma pyridoxal-5′-phosphate (PLP) rises due to impaired metabolism, poor clearance, cofactor imbalances, subtle genetic deficits, insidious overconsumption, and more. And it’s much more common than most clinicians realize. This often leads to symptoms like tingling, anxiety, or autonomic dysfunction, even in the absence of any direct B6 supplement use. Here’s what causes it and what to do about it:

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Dr. Malek and the MTHFRSolve Team
The Biochemical Reality of B6 Toxicity, Neuropathy, and Functional Overload
Malek Hamed, MD
The Biochemical Reality of B6 Toxicity, Neuropathy, and Functional Overload
Malek Hamed, MD

Vitamin B6 is everywhere—multivitamins, B-complexes, prenatal supplements, even hydration powders. It’s recommended for everything from PMS to anxiety to neuropathy. But for a growing number of people, it’s making things worse.

Burning feet, vivid dreams, facial tension, and inexplicable panic episodes aren’t random—they’re often early signs of B6 overload. This isn’t a simple case of “too much of a good thing.” It’s a genuine biochemical derailment that can mimic everything from MCAS to mold illness.

In this article, I’ll walk you through the actual physiology of B6 sensitivity—why standard blood tests are misleading, why P5P (i.e. PLP) often worsens symptoms, and what it really takes to recover. This is for the people who were told B6 was safe and now cannot sleep, think, or feel like themselves.

~ Dr. Malek

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Malek Hamed, MD
The Slow COMT Roadmap
Malek Hamed, MD
The Slow COMT Roadmap
Malek Hamed, MD

Dear Slow COMTer,

The goal of this roadmap is to give you the most direct, straightforward, actionable slow COMT plan possible.

If you've already run genetic testing (like 23andMe or AncestryDNA), you may want to confirm that you're carrying the COMT V158M variant, especially the homozygous (Val/Val) or heterozygous (Val/Met) form, though the latter is less of a concern unless you have symptoms associated with slow COMT.

This roadmap assumes you do, and that you’ve either seen classic symptoms

Read More →
Malek Hamed, MD

FAQs

  • No. If you already have genetic data (from a test like 23andMe), you can upload it for analysis. If you don’t have any data yet and live in Florida, Texas, Arizona, or Minnesota, you can order one of our in-house test kits. If you're outside those states, you're still eligible for supplement plans or consultations based on data you already have — or based on your symptoms and goals, without any data at all.

  • If you ordered a supplement plan:
    You'll receive a secure upload form to submit your existing genetic data (and labs, if applicable). Once uploaded, Dr. Malek personally reviews your case and creates a phased plan tailored to your biology.

    If you ordered a test kit:
    You'll receive the kit within a few days. After your results are processed, Dr. Malek will build your supplement plan automatically — no upload or intake form required — and sent it to your email.

  • Only if you live in Florida, Texas, Arizona, or Minnesota. In those states, services may be delivered under Dr. Malek’s medical license. If you live elsewhere, your consultation or supplement plan will be provided for educational and wellness purposes only. Either way, you’ll receive in-depth, personalized guidance — always based on real data and careful analysis.

  • Use the guide above to choose based on your location and what data you already have. If you’re still unsure, just send us a quick message and we’ll help you decide.

  • Yes — we include detailed notes and instructions with every plan. However, if you need even more clarity or want to go deeper, you can always book a consultation afterward. Video consultations are not included, unless you get the Ultimate Methylation Package. For in-state clients, follow-up may fall under medical care depending on your situation.

  • These plans are for individuals who want a highly personalized supplement strategy based on their unique genetics and (optionally) labs and personal history. If you’ve felt unaddressed by one-size-fits-all protocols or experienced negative reactions to supplements in the past, this approach offers you a more targeted alternative.

  • Plan 1: Gene-Based Methylation Plan
    Focuses on specific SNPs that Dr. Malek uses in his in-house methylation and COMT panel. You’ll upload your raw genetic file (e.g. from 23andMe), and the plan will be based on those high-impact gene markers.

    Plan 2: Full Data Integration Plan
    Includes everything in Plan 1 — plus the option to submit recent labwork, background history, symptoms, and anything else you feel is relevant. The plan you receive reflects a deeper level of integration across your biology, not just your DNA.

  • You can upload your raw genetic data from services like 23andMe, AncestryDNA, or any other platform that allows access to your raw SNP data. We’ll provide a secure, HIPAA-compliant upload form after purchase.

    If for whatever reason we determine that your results simply are not sufficient for analysis, we will reach out to you with the option to either refund your payment or obtain further detail.

  • No. You can provide lab results if you choose the Full Data Integration version of the supplement plan or a Video Consultation and want them factored into your strategy. Otherwise, no lab results required.

  • You’ll typically receive your plan within 3–5 business days after uploading your data and completing the intake form. Full Data integration options may require up to 10 days, depending on case complexity.

  • For kits and supplement plans (unless otherwise noted), you’ll receive:

    • A phased supplement plan based on your data

    • Exact nutrient forms and dosages

    • Suggested timing and sequencing (e.g. Tier 1 → Tier 2)

    • Non-affiliated brand recommendations

    • Insights about your key SNPs and how they relate to your plan

  • These plans are designed to support your biology — not to diagnose or treat any disease. While many people experience improvements in energy, focus, mood, sleep, and many other symptoms, results vary and depend on multiple factors. What we offer is clarity, direction, and a highly strategic place to start.

  • Yes. You always have the option to book a consultation with Dr. Malek (medical or educational, depending on your location) to work on your health—with or without genetic data. These can be in the form of a follow-up to adjust your plan based on how you’re responding or if you want to go deeper. Consultations are not included with our supplement plans and kits, other than the Ultimate Methylation Package.

  • Reach out to admin@malekmd.com and we’ll be happy to help.

FAQs

(for the Comprehensive Methylation Panel)

  • Our test is conducted via the same method as Gary Brecka's test, i.e. via cheek swab. Gary Brecka's base 10X test covers 5 key methylation genes: COMT, AHCY, MTRR, MTR, and MTHFR. Our Comprehensive Methylation Panel + COMT testing kit includes over 20 genes to give you a deeper understanding of what nutritional, supplemental, and lifestyle changes you need to make to improve your methylation status.

  • There are no hidden fees. You pay a one-time flat-fee for your kit, and shipping is free. Your kit comes with a pre-included shipping label so you don’t have to pay for return shipping back to the laboratory.

  • Your sample is obtained via a simple cheek swab—the same as the method used by, for example, Gary Brecka’s cheek swab test.

  • There are a lot of supplements that can affect the way your body methylates: Things like methylcobalamin, methylfolate, magnesium, NAC, and much more. For some people, these will help, but for others, they can actually hurt. A better question is: What supplements will help my body with methylation? What does my body need to start methylating better. To figure that out, you need to get testing. Check out our genetic tests to get started.

  • Genetic testing is provided in collaboration with third-party labs. We generally collaborate with Fagron lab in Texas.

  • If there’s a SNP you’re wanting to test that you don’t see listed, just email us or give us a call. We have the capacity to test many different SNPs, including things like APOE, MAO-A/B, and much more.

  • For the genetic testing specifically, I serve all of Texas, Florida, Minnesota, and Arizona, so whether you’re in a bigger city like Houston, Dallas, Jacksonville, or Minneapolis, or a smaller town out in no-man’s land, you can get my genetic testing.

Still not sure where to begin? Contact us →

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Questions?

Send us an email and I (or my team) will do our best to get back to you.

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