Managing slow COMT variants requires a tailored mix of (balanced) methylation-supporting strategies, neurotransmitter-modulating strategies, and so on. However, these measures may at times clash with those required for the management of sulfur intolerances.

Starting with the most general question—i.e. how much protein should someone with slow or fast COMT function consume—my answer is pretty straightforward…

Generally speaking, if you have a “mutation” in this gene, what that really means is that you have an under-functioning polymorphism that is less effective at breaking down dopamine, estrogen, and other metabolites…

As you may remember from our previous articles, catechol-O-methyltransferase (COMT) is an enzyme that breaks down catecholamines (most relevantly, dopamine), undesirable forms of estrogen, and other toxic substances in the body…

There is a society-level push to distance humans from human nature.

Consider the claim commonly made by health influencers and media pundits that “just because something is ‘natural’ it doesn’t mean that it’s ‘better.’”

Then just look at the sheer number of articles written…

SAMe is found in virtually every single cell in your body.

It’s involved in producing neurotransmitters like serotonin and dopamine, detoxifying the liver from toxins and alcohol, supporting the gut-brain connection, and even regulating the expression of your own genetic code.

The CBS gene is an incredibly important gene that can affects things like your mood, perceived energy levels, susceptibility to heart disease and cancer, your ability to tolerate high protein diets, and a lot more.

Caffeine (through coffee, tea, or otherwise) has the clear potential to interact with different COMT variants in different ways. I discussed some of this in a previous article, where I covered how caffeine can actually increase the risk of heart attacks in people with slow COMT variants. But what about fast COMT variants…

Pain is a very subjective experience. What barely perturbs one person can be enough to utterly upend another’s life entirely. This applies to physical pain—things like thorn pricks, broken bones, etc.—as well as emotional and psychological pain…

Coffee is not being used as it should. And this is problematic for everyone, but it is especially so for people with specific genetic variants.

Catechol-O-methyltransferase, or COMT as it’s more commonly known, is an enzyme that’s responsible for breaking down a variety of different compounds in the body. This includes things like: Dopamine—an important neurotransmitter…

The spike protein—that protein encoded both by the COVID virus and the COVID vaccine—is a particularly nasty protein. It’s been found to distribute itself throughout the body’s tissues after vaccination or infection, accumulating in various bodily tissues and organs, causing untold harm to the thyroid gland, the brain, the reproductive organs, and more.

Chronic, systemic inflammation is an extremely common problem, especially in the hyper-modern, first-world type environments that so many of us live in. So many of the patients that I work with—people with conditions from fibromyalgia and chronic fatigue to hypothyroidism and IBS—have full-body, long-term inflammation as a key underlying component of their conditions.

How do you know if you need additional methylation genetic testing, above and beyond MTHFR testing?

Obsessive-compulsive disorder (OCD) is more common than you may think. Around 1 in 40 people develop it at some point in their life, and it can be quite debilitating. People with OCD experience intrusive, unshakeable thoughts as well as compulsive behaviors.

How can a methylation problem cause SIBO? One of the most important components of the digestive process is the production and release of bile—a liquid substance containing fat emulsification and other digestive factors produced by the liver and released from the gallbladder…