Slow COMT in the Context of Sulfur Intolerance

Note: This article will only be available for free for 24 hours. Afterwards, it will be available exclusively to Slow COMT Roadmap members.

This article is written in response to a question from a Roadmap subscriber.

Note that this article is intended to be purely informational and educational in nature. I do not recommend that you take any supplements or implement any measures mentioned in this article without discussing with your primary care doctor beforehand.

Slow COMT “mutations” afflict a reasonable percentage of the population, leading to deficits in processing of catecholamines (dopamine and adrenalines), estrogen, and some toxic compounds.

Managing slow COMT variants requires a tailored mix of (balanced) methylation-supporting strategies, neurotransmitter-modulating strategies, and so on. However, these measures may at times clash with those required for the management of sulfur intolerances.

To begin:

What are the symptoms of sulfur intolerance?

Sulfur intolerance can cause a vast array of different symptoms touching virtually every bodily system, this includes things like:

• Chronic fatigue and metabolic issues (due to poor energy processing mediated by select sulfur metabolites)

• Neurological and psychiatric issues, including anxiety, depression, insomnia, etc. (due to the stimulating effects of certain sulfur metabolites)

• Hormonal problems, including PMS, pregnancy-related symptoms, and low-testosterone-like symptoms (due to estrogenic effects)

• Nausea/diarrhea

• Food and supplement intolerances

• And more…

So how do you know for sure whether you have a sulfur intolerance?

There’s no standardized way to know for sure; rather, it’s more of an integrative judgement considering your symptoms, response to sulfur-containing foods and supplements/medications, and—if possible—some lab testing.

Specifically, testing plasma amino acids tends to be helpful in not only diagnosing the problem but also determining how it needs to be fixed for any given person. The most important amino acids to test are:

The rest of this article is available exclusively to Slow COMT Roadmap members. Your first month of the Roadmap is FREE.

A note from Dr. Malek:

If you’re interested in helping support my work, the best thing you can do is help share my website. Consider linking my blog posts on your social media pages, reddit forums, etc. It’s not easy competing with multimillion-dollar healthcare behemoths, so your help in amplifying a relatively small voice really goes a long way. Thank you :)

~Dr. Malek

Keep in mind that this is not official medical advice. No doctor-patient relationship is established through this article or through any other information provided on this website.